Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors

Numerous studies have shown the recovery of auditory function in mouse models of genetic hearing loss following AAV gene therapy, yet translation to the clinic has not yet been demonstrated. One limitation has been the lack of human inner ear cell lines or tissues for validating viral gene therapies...

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Detalles Bibliográficos
Autores principales: van Beelen, Edward S. A., van der Valk, Wouter H., Verhagen, Thijs O., de Groot, John C. M. J., Madison, Margot A., Shadmanfar, Wijs, Hensen, Erik F., Jansen, Jeroen C., van Benthem, Peter Paul G., Holt, Jeffrey R., Locher, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221426/
https://www.ncbi.nlm.nih.gov/pubmed/35740941
http://dx.doi.org/10.3390/biom12060816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221426/
https://www.ncbi.nlm.nih.gov/pubmed/35740941
http://dx.doi.org/10.3390/biom12060816

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