The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous BRCA(MUT) and BRCA(WT) Ovarian Cancer Cells

Olaparib is a poly (ADP-ribose) polymerase inhibitor (PARPi) that inhibits PARP1/2, leading to replication-induced DNA damage that requires homologous recombination repair. Olaparib is often insufficient to treat BRCA-mutated (BRCA(MUT)) and BRCA wild-type (BRCA(WT)) high-grade serous ovarian carcin...

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Detalles Bibliográficos
Autores principales: Gralewska, Patrycja, Gajek, Arkadiusz, Rybaczek, Dorota, Marczak, Agnieszka, Rogalska, Aneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221516/
https://www.ncbi.nlm.nih.gov/pubmed/35741017
http://dx.doi.org/10.3390/cells11121889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221516/
https://www.ncbi.nlm.nih.gov/pubmed/35741017
http://dx.doi.org/10.3390/cells11121889

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