Cargando…

Intranasal Delivery of Darunavir-Loaded Mucoadhesive In Situ Gel: Experimental Design, In Vitro Evaluation, and Pharmacokinetic Studies

The clinical efficacy of antiretroviral therapy in NeuroAIDS is primarily limited by the low perfusion of the drug to the brain. The objective of the current investigation was to design and develop an in situ mucoadhesive gel loaded with darunavir to assess the feasibility of brain targeting through...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nair, Anroop B., Chaudhary, Sunita, Shah, Hiral, Jacob, Shery, Mewada, Vivek, Shinu, Pottathil, Aldhubiab, Bandar, Sreeharsha, Nagaraja, Venugopala, Katharigatta N., Attimarad, Mahesh, Shah, Jigar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223067/ https://www.ncbi.nlm.nih.gov/pubmed/35735686 http://dx.doi.org/10.3390/gels8060342

Ejemplares similares

Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System Derived Tablet Containing Sertraline
por: Nair, Anroop B., et al.
Publicado: (2022)

Experimental design, formulation and in vivo evaluation of a novel topical in situ gel system to treat ocular infections
por: Nair, Anroop B., et al.
Publicado: (2021)

HPMC- and PLGA-Based Nanoparticles for the Mucoadhesive Delivery of Sitagliptin: Optimization and In Vivo Evaluation in Rats
por: Nair, Anroop B., et al.
Publicado: (2019)

Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation
por: Nair, Anroop B., et al.
Publicado: (2021)

Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting
por: Nair, Anroop B., et al.
Publicado: (2023)

Design, Development, and Evaluation of Constant Voltage Iontophoresis for the Transungual Delivery of Efinaconazole
por: Nair, Anroop B., et al.
Publicado: (2023)

Clarithromycin Solid Lipid Nanoparticles for Topical Ocular Therapy: Optimization, Evaluation, and In Vivo Studies
por: Nair, Anroop B., et al.
Publicado: (2021)

Development and Validation of Green UV Derivative Spectrophotometric Methods for Simultaneous Determination Metformin and Remogliflozin from Formulation: Evaluation of Greenness
por: Attimarad, Mahesh, et al.
Publicado: (2021)

Effective Therapeutic Delivery and Bioavailability Enhancement of Pioglitazone Using Drug in Adhesive Transdermal Patch
por: Nair, Anroop B., et al.
Publicado: (2019)

Development of Asialoglycoprotein Receptor-Targeted Nanoparticles for Selective Delivery of Gemcitabine to Hepatocellular Carcinoma
por: Nair, Anroop B., et al.
Publicado: (2019)

Design, Development, Evaluation, and In Vivo Performance of Buccal Films Embedded with Paliperidone-Loaded Nanostructured Lipid Carriers
por: AlMulhim, Fahad Mohammed, et al.
Publicado: (2023)

Qbd-Based Approach to Optimize Niosomal Gel of Levosulpiride for Transdermal Drug Delivery
por: Alnaim, Ahmed S., et al.
Publicado: (2023)

Mucoadhesive buccal film of almotriptan improved therapeutic delivery in rabbit model
por: Nair, Anroop B., et al.
Publicado: (2020)

Constant Voltage Iontophoresis Technique to Deliver Terbinafine via Transungual Delivery System: Formulation Optimization Using Box–Behnken Design and In Vitro Evaluation
por: Nair, Anroop B., et al.
Publicado: (2021)

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management
por: Jacob, Shery, et al.
Publicado: (2021)

Mucoadhesive Particles: A Novel, Prolonged-Release Nanocarrier of Sitagliptin for the Treatment of Diabetics
por: SreeHarsha, Nagaraja, et al.
Publicado: (2019)

Monitoring of Non-β-Lactam Antibiotic Resistance-Associated Genes in ESBL Producing Enterobacterales Isolates
por: Shinu, Pottathil, et al.
Publicado: (2020)

Design, Development, and Evaluation of Treprostinil Embedded Adhesive Transdermal Patch
por: Alissa, Ibrahim, et al.
Publicado: (2023)

Correction: Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
por: Attimarad, Mahesh, et al.
Publicado: (2019)

Computational Design, Synthesis, and Pharmacological Evaluation of Naproxen-Guaiacol Chimera for Gastro-Sparing Anti-Inflammatory Response by Selective COX2 Inhibition
por: Shinu, Pottathil, et al.
Publicado: (2022)

Computational, crystallographic studies, cytotoxicity and anti-tubercular activity of substituted 7-methoxy-indolizine analogues
por: Venugopala, Katharigatta Narayanaswamy, et al.
Publicado: (2019)

Progress Report: Antimicrobial Drug Discovery in the Resistance Era
por: Shinu, Pottathil, et al.
Publicado: (2022)

An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles
por: SreeHarsha, Nagaraja, et al.
Publicado: (2019)

Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion
por: Harsha, Sree N, et al.
Publicado: (2015)

Lipid Nanoparticles as a Promising Drug Delivery Carrier for Topical Ocular Therapy—An Overview on Recent Advances
por: Jacob, Shery, et al.
Publicado: (2022)

Formulation, Characterization, Anti-Inflammatory and Cytotoxicity Study of Sesamol-Laden Nanosponges
por: Nair, Anroop B., et al.
Publicado: (2022)

Sensitivity Enhanced Ecofriendly UV Spectrophotometric Methods for Quality Control of Telmisartan and Benidipine Formulations: Comparison of Whiteness and Greenness with HPLC Methods
por: Chohan, Muhammad Shahzad, et al.
Publicado: (2022)

Solid Lipid Nanoparticles Embedded Hydrogels as a Promising Carrier for Retarding Irritation of Leflunomide
por: Alhelal, Hawra Mohammed, et al.
Publicado: (2023)

Anti-Tubercular Activity of Substituted 7-Methyl and 7-Formylindolizines and In Silico Study for Prospective Molecular Target Identification
por: Venugopala, Katharigatta N., et al.
Publicado: (2019)

Papain-cetylpyridinium chloride and pepsin-cetylpyridinium chloride; two novel, highly sensitive, concentration, digestion and decontamination techniques for culturing mycobacteria from clinically suspected pulmonary tuberculosis cases
por: Shinu, Pottathil, et al.
Publicado: (2020)

Crystallography, Molecular Modeling, and COX-2 Inhibition Studies on Indolizine Derivatives
por: Venugopala, Katharigatta N., et al.
Publicado: (2021)

Tocotrienol in the Treatment of Topical Wounds: Recent Updates
por: Nair, Anroop B., et al.
Publicado: (2022)

In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis
por: Venugopala, Katharigatta N, et al.
Publicado: (2020)

Novel Series of Methyl 3-(Substituted Benzoyl)-7-Substituted-2-Phenylindolizine-1-Carboxylates as Promising Anti-Inflammatory Agents: Molecular Modeling Studies
por: Venugopala, Katharigatta N., et al.
Publicado: (2019)

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems
por: Jacob, Shery, et al.
Publicado: (2021)

Larvicidal Activities of 2-Aryl-2,3-Dihydroquinazolin -4-ones against Malaria Vector Anopheles arabiensis, In Silico ADMET Prediction and Molecular Target Investigation
por: Venugopala, Katharigatta N., et al.
Publicado: (2020)

Enhancement in antinociceptive and anti-inflammatory effects of tramadol by transdermal proniosome gel
por: Shah, Jigar, et al.
Publicado: (2020)

Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls
por: Shinu, Pottathil, et al.
Publicado: (2022)

Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
por: Attimarad, Mahesh, et al.
Publicado: (2019)

Optimized Rivastigmine Nanoparticles Coated with Eudragit for Intranasal Application to Brain Delivery: Evaluation and Nasal Ciliotoxicity Studies
por: Bhanderi, Mansi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vpqagdnscsml2egqslvhbmmn74