MarZIC: A Marginal Mediation Model for Zero-Inflated Compositional Mediators with Applications to Microbiome Data

Background: The human microbiome can contribute to pathogeneses of many complex diseases by mediating disease-leading causal pathways. However, standard mediation analysis methods are not adequate to analyze the microbiome as a mediator due to the excessive number of zero-valued sequencing reads in...

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Detalles Bibliográficos
Autores principales: Wu, Quran, O’Malley, James, Datta, Susmita, Gharaibeh, Raad Z., Jobin, Christian, Karagas, Margaret R., Coker, Modupe O., Hoen, Anne G., Christensen, Brock C., Madan, Juliette C., Li, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223163/
https://www.ncbi.nlm.nih.gov/pubmed/35741811
http://dx.doi.org/10.3390/genes13061049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223163/
https://www.ncbi.nlm.nih.gov/pubmed/35741811
http://dx.doi.org/10.3390/genes13061049

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