Distinct developmental and degenerative functions of SARM1 require NAD(+) hydrolase activity

SARM1 is the founding member of the TIR-domain family of NAD(+) hydrolases and the central executioner of pathological axon degeneration. SARM1-dependent degeneration requires NAD(+) hydrolysis. Prior to the discovery that SARM1 is an enzyme, SARM1 was studied as a TIR-domain adaptor protein with no...

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Detalles Bibliográficos
Autores principales: Brace, E. J., Essuman, Kow, Mao, Xianrong, Palucki, John, Sasaki, Yo, Milbrandt, Jeff, DiAntonio, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223315/
https://www.ncbi.nlm.nih.gov/pubmed/35737728
http://dx.doi.org/10.1371/journal.pgen.1010246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223315/
https://www.ncbi.nlm.nih.gov/pubmed/35737728
http://dx.doi.org/10.1371/journal.pgen.1010246

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