Cargando…
Distinct developmental and degenerative functions of SARM1 require NAD(+) hydrolase activity
SARM1 is the founding member of the TIR-domain family of NAD(+) hydrolases and the central executioner of pathological axon degeneration. SARM1-dependent degeneration requires NAD(+) hydrolysis. Prior to the discovery that SARM1 is an enzyme, SARM1 was studied as a TIR-domain adaptor protein with no...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223315/ https://www.ncbi.nlm.nih.gov/pubmed/35737728 http://dx.doi.org/10.1371/journal.pgen.1010246 |