Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Deletion but Not Inhibition of Extracellular PCSK9 Reduces Infarct Sizes Ex Vivo but Not In Vivo

Hypoxia upregulates PCSK9 expression in the heart, and PCSK9 affects the function of myocytes. This study aimed to investigate the impact of PCSK9 on reperfusion injury in rats and mice fed normal or high-fat diets. Either the genetic knockout of PCSK9 (mice) or the antagonism of circulating PCSK9 v...

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Detalles Bibliográficos
Autores principales: Schreckenberg, Rolf, Wolf, Annemarie, Szabados, Tamara, Gömöri, Kamilla, Szabó, István Adorján, Ágoston, Gergely, Brenner, Gábor, Bencsik, Péter, Ferdinandy, Péter, Schulz, Rainer, Schlüter, Klaus-Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223354/
https://www.ncbi.nlm.nih.gov/pubmed/35742954
http://dx.doi.org/10.3390/ijms23126512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223354/
https://www.ncbi.nlm.nih.gov/pubmed/35742954
http://dx.doi.org/10.3390/ijms23126512

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