Arsenic Trioxide and Venetoclax Synergize against AML Progenitors by ROS Induction and Inhibition of Nrf2 Activation

Venetoclax (VEN) in combination with hypomethylating agents induces disease remission in patients with de novo AML, however, most patients eventually relapse. AML relapse is attributed to the persistence of drug-resistant leukemia stem cells (LSCs). LSCs need to maintain low intracellular levels of...

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Detalles Bibliográficos
Autores principales: Hoang, Dinh Hoa, Buettner, Ralf, Valerio, Melissa, Ghoda, Lucy, Zhang, Bin, Kuo, Ya-Huei, Rosen, Steven T., Burnett, John, Marcucci, Guido, Pullarkat, Vinod, Nguyen, Le Xuan Truong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223383/
https://www.ncbi.nlm.nih.gov/pubmed/35743010
http://dx.doi.org/10.3390/ijms23126568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223383/
https://www.ncbi.nlm.nih.gov/pubmed/35743010
http://dx.doi.org/10.3390/ijms23126568

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