Cargando…

Dysregulated Brain Protein Phosphorylation Linked to Increased Human Tau Expression in the hTau Transgenic Mouse Model

Altered protein phosphorylation is a major pathologic modification in tauopathies and Alzheimer’s disease (AD) linked to abnormal tau fibrillar deposits in neurofibrillary tangles (NFTs) and pre-tangles and β-amyloid deposits in AD. hTau transgenic mice, which express 3R and less 4R human tau with n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferrer, Isidro, Andrés-Benito, Pol, Ausín, Karina, Cartas-Cejudo, Paz, Lachén-Montes, Mercedes, del Rio, José Antonio, Fernández-Irigoyen, Joaquín, Santamaría, Enrique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223516/ https://www.ncbi.nlm.nih.gov/pubmed/35742871 http://dx.doi.org/10.3390/ijms23126427

Ejemplares similares

Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory–entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases
por: Cartas-Cejudo, Paz, et al.
Publicado: (2023)

Common and Specific Marks of Different Tau Strains Following Intra-Hippocampal Injection of AD, PiD, and GGT Inoculum in hTau Transgenic Mice
por: Ferrer, Isidro, et al.
Publicado: (2022)

Deregulated Transcription and Proteostasis in Adult mapt Knockout Mouse
por: Andrés-Benito, Pol, et al.
Publicado: (2023)

Tackling the Biological Meaning of the Human Olfactory Bulb Dyshomeostatic Proteome across Neurological Disorders: An Integrative Bioinformatic Approach
por: Cartas-Cejudo, Paz, et al.
Publicado: (2021)

Amyotrophic Lateral Sclerosis Is Accompanied by Protein Derangements in the Olfactory Bulb-Tract Axis
por: Lachén-Montes, Mercedes, et al.
Publicado: (2020)

Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum
por: Andrés-Benito, Pol, et al.
Publicado: (2022)

Olfactory Bulb Proteomics Reveals Widespread Proteostatic Disturbances in Mixed Dementia and Guides for Potential Serum Biomarkers to Discriminate Alzheimer Disease and Mixed Dementia Phenotypes
por: Lachén-Montes, Mercedes, et al.
Publicado: (2021)

Dysregulated protein phosphorylation: A determining condition in the continuum of brain aging and Alzheimer's disease
por: Ferrer, Isidro, et al.
Publicado: (2021)

Constant Levels of Tau Phosphorylation in the Brain of htau Mice
por: Neddens, Joerg, et al.
Publicado: (2020)

Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy
por: Ferrer, Isidro, et al.
Publicado: (2020)

Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer’s disease progression
por: Lachén-Montes, Mercedes, et al.
Publicado: (2017)

Codonopsis pilosula Polysaccharide Attenuates Tau Hyperphosphorylation and Cognitive Impairments in hTau Infected Mice
por: Zhang, Qing, et al.
Publicado: (2018)

Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation
por: Barron, Matthew R., et al.
Publicado: (2020)

Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer’s Disease
por: Lachen-Montes, Mercedes, et al.
Publicado: (2019)

P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities
por: Xie, Jia‐Zhao, et al.
Publicado: (2022)

Network-Driven Proteogenomics Unveils an Aging-Related Imbalance in the Olfactory IκBα-NFκB p65 Complex Functionality in Tg2576 Alzheimer’s Disease Mouse Model
por: Palomino-Alonso, Maialen, et al.
Publicado: (2017)

Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre‐symptomatic female but not male htau mice
por: Bretland, Katie A., et al.
Publicado: (2021)

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology
por: Gratuze, Maud, et al.
Publicado: (2017)

In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in htau Mice
por: Davidowitz, Eliot J., et al.
Publicado: (2020)

Amyloid-Driven Tau Accumulation on Mitochondria Potentially Leads to Cognitive Deterioration in Alzheimer’s Disease
por: Cuadrado-Tejedor, Mar, et al.
Publicado: (2021)

Alteration in the Cerebrospinal Fluid Lipidome in Parkinson’s Disease: A Post-Mortem Pilot Study
por: Fernández-Irigoyen, Joaquín, et al.
Publicado: (2021)

Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice
por: Qian, Shuo, et al.
Publicado: (2018)

Neuroanatomical Quantitative Proteomics Reveals Common Pathogenic Biological Routes between Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
por: Iridoy, Marina Oaia, et al.
Publicado: (2018)

Involvement of Oligodendrocytes in Tau Seeding and Spreading in Tauopathies
por: Ferrer, Isidro, et al.
Publicado: (2019)

Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit
por: Liu, Xinghua, et al.
Publicado: (2017)

Effect of treadmill exercise on PI3K/AKT/mTOR, autophagy, and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice
por: Kang, Eun-Bum, et al.
Publicado: (2015)

Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis
por: Lachén-Montes, Mercedes, et al.
Publicado: (2020)

Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions
por: Lachén-Montes, Mercedes, et al.
Publicado: (2022)

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice
por: Gamache, Julia, et al.
Publicado: (2019)

Progressive modulation of the human olfactory bulb transcriptome during Alzheimer´s disease evolution: novel insights into the olfactory signaling across proteinopathies
por: Lachen-Montes, Mercedes, et al.
Publicado: (2017)

Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia
por: Hull, Claire, et al.
Publicado: (2019)

Treatment With Nilvadipine Mitigates Inflammatory Pathology and Improves Spatial Memory in Aged hTau Mice After Repetitive Mild TBI
por: Morin, Alexander, et al.
Publicado: (2018)

Cannabis Use Induces Distinctive Proteomic Alterations in Olfactory Neuroepithelial Cells of Schizophrenia Patients
por: Barrera-Conde, Marta, et al.
Publicado: (2021)

Olfactory Characterization and Training in Older Adults: Protocol Study
por: Zambom-Ferraresi, Fabíola, et al.
Publicado: (2021)

Differences in Tau Seeding in Newborn and Adult Wild-Type Mice
por: Ferrer, Isidro, et al.
Publicado: (2022)

Proteomic Characterization of the Olfactory Molecular Imbalance in Dementia with Lewy Bodies
por: Lachén-Montes, Mercedes, et al.
Publicado: (2020)

Induction of Oxidative Stress in SH-SY5Y Cells by Overexpression of hTau40 and Its Mitigation by Redox-Active Nanoparticles
por: Pieńkowska, Natalia, et al.
Publicado: (2022)

Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI(2)/Tau Transgenic Mice
por: Garringer, Holly J., et al.
Publicado: (2013)

Effects of Resveratrol and Morin on Insoluble Tau in Tau Transgenic Mice
por: Yu, Kwun Chung, et al.
Publicado: (2018)

Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease
por: Fossati, Silvia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_f44o8fdg7hf933um89ji3e5eiu