Copper-Binding Domain Variation in a Novel Murine Lysyl Oxidase Model Produces Structurally Inferior Aortic Elastic Fibers Whose Failure Is Modified by Age, Sex, and Blood Pressure

Lysyl oxidase (LOX) is a copper-binding enzyme that cross-links elastin and collagen. The dominant LOX variation contributes to familial thoracic aortic aneurysm. Previously reported murine Lox mutants had a mild phenotype and did not dilate without drug-induced provocation. Here, we present a new,...

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Detalles Bibliográficos
Autores principales: Tsang, Kit Man, Knutsen, Russell H., Billington, Charles J., Lindberg, Eric, Steenbock, Heiko, Fu, Yi-Ping, Wardlaw-Pickett, Amanda, Liu, Delong, Malide, Daniela, Yu, Zu-Xi, Bleck, Christopher K. E., Brinckmann, Jürgen, Kozel, Beth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223555/
https://www.ncbi.nlm.nih.gov/pubmed/35743192
http://dx.doi.org/10.3390/ijms23126749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223555/
https://www.ncbi.nlm.nih.gov/pubmed/35743192
http://dx.doi.org/10.3390/ijms23126749

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