Ligation of TLR Homologue CD180 of B Cells Activates the PI3K/Akt/mTOR Pathway in Systemic Sclerosis and Induces a Pathological Shift in the Expression of BAFF Receptors

The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) pathways are known to play a key role in B-cell activation and fibrosis in systemic sclerosis (SSc). Receptors of B-cell activator factor (BAFF) utilize these pathways, which can be influenced by Toll-like rece...

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Detalles Bibliográficos
Autores principales: Erdő-Bonyár, Szabina, Rapp, Judit, Szinger, Dávid, Minier, Tünde, Kumánovics, Gábor, Czirják, László, Berki, Timea, Simon, Diána
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223596/
https://www.ncbi.nlm.nih.gov/pubmed/35743222
http://dx.doi.org/10.3390/ijms23126777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223596/
https://www.ncbi.nlm.nih.gov/pubmed/35743222
http://dx.doi.org/10.3390/ijms23126777

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