Galunisertib Exerts Antifibrotic Effects on TGF-β-Induced Fibroproliferative Dermal Fibroblasts

Dermal fibroblasts in pathological scars secrete constitutively elevated levels of TGF-β, signaling the transcription of fibrotic genes via activin-like kinase 5 (ALK5). In the present study, we examine the antifibrotic effects of galunisertib, a small-molecule inhibitor of ALK5, on fibroproliferati...

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Detalles Bibliográficos
Autores principales: Peterson, Joshua M., Jay, Jayson W., Wang, Ye, Joglar, Alejandro A., Prasai, Anesh, Palackic, Alen, Wolf, Steven E., El Ayadi, Amina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223605/
https://www.ncbi.nlm.nih.gov/pubmed/35743131
http://dx.doi.org/10.3390/ijms23126689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223605/
https://www.ncbi.nlm.nih.gov/pubmed/35743131
http://dx.doi.org/10.3390/ijms23126689

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