The Unfolded Protein Response Sensor PERK Mediates Stiffness-Dependent Adaptation in Glioblastoma Cells

Glioblastoma multiforme (GBM) is the most aggressive brain tumor in adults. In addition to genetic causes, the tumor microenvironment (TME), including stiffening of the extracellular matrix (ECM), is a main driver of GBM progression. Mechano-transduction and the unfolded protein response (UPR) are e...

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Detalles Bibliográficos
Autores principales: Khoonkari, Mohammad, Liang, Dong, Lima, Marina Trombetta, van der Land, Tjitze, Liang, Yuanke, Sun, Jianwu, Dolga, Amalia, Kamperman, Marleen, van Rijn, Patrick, Kruyt, Frank A. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223606/
https://www.ncbi.nlm.nih.gov/pubmed/35742966
http://dx.doi.org/10.3390/ijms23126520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223606/
https://www.ncbi.nlm.nih.gov/pubmed/35742966
http://dx.doi.org/10.3390/ijms23126520

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