New Borane-Protected Derivatives of α-Aminophosphonous Acid as Anti-Osteosarcoma Agents: ADME Analysis and Molecular Modeling, In Vitro Studies on Anti-Cancer Activities, and NEP Inhibition as a Possible Mechanism of Anti-Proliferative Activity

Many organophosphorus compounds (OPs), especially various α-aminophosphonates, exhibit anti-cancer activities. They act, among others, as inhibitors of the proteases implicated in cancerogenesis. Thesetypes of inhibitors weredescribed, e.g., for neutral endopeptidase (NEP) expressed in different can...

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Detalles Bibliográficos
Autores principales: Mizerska-Kowalska, Magdalena, Sowa, Sylwia, Donarska, Beata, Płaziński, Wojciech, Sławińska-Brych, Adrianna, Tomasik, Aleksandra, Ziarkowska, Anna, Łączkowski, Krzysztof Z., Zdzisińska, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223658/
https://www.ncbi.nlm.nih.gov/pubmed/35743158
http://dx.doi.org/10.3390/ijms23126716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223658/
https://www.ncbi.nlm.nih.gov/pubmed/35743158
http://dx.doi.org/10.3390/ijms23126716

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