Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss

Evidence indicates that inhalative anesthetics enhance the β-site amyloid precursor protein (APP)-cleaving enzyme (BACE) activity, increase amyloid beta 1-42 (Aβ(1–42)) aggregation, and modulate dendritic spine dynamics. However, the mechanisms of inhalative anesthetics on hippocampal dendritic spin...

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Detalles Bibliográficos
Autores principales: Wang, Xingxing, Shi, Qinfang, Pradhan, Arpit Kumar, Ziegon, Laura, Schlegel, Martin, Rammes, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223703/
https://www.ncbi.nlm.nih.gov/pubmed/35743082
http://dx.doi.org/10.3390/ijms23126637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223703/
https://www.ncbi.nlm.nih.gov/pubmed/35743082
http://dx.doi.org/10.3390/ijms23126637

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