Cargando…

Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss

Evidence indicates that inhalative anesthetics enhance the β-site amyloid precursor protein (APP)-cleaving enzyme (BACE) activity, increase amyloid beta 1-42 (Aβ(1–42)) aggregation, and modulate dendritic spine dynamics. However, the mechanisms of inhalative anesthetics on hippocampal dendritic spin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xingxing, Shi, Qinfang, Pradhan, Arpit Kumar, Ziegon, Laura, Schlegel, Martin, Rammes, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223703/ https://www.ncbi.nlm.nih.gov/pubmed/35743082 http://dx.doi.org/10.3390/ijms23126637

Ejemplares similares

Quantification of astrocytic synaptic pruning in mouse hippocampal slices in response to ex vivo Aβ treatment via colocalization analysis with C1q
por: Pradhan, Arpit Kumar, et al.
Publicado: (2022)

An Intracellular Threonine of Amyloid-β Precursor Protein Mediates Synaptic Plasticity Deficits and Memory Loss
por: Lombino, Franco, et al.
Publicado: (2013)

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease
por: Zhang, Zhentao, et al.
Publicado: (2015)

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2
por: Yan, Riqiang
Publicado: (2017)

Netrin-1: A Modulator of Macrophage Driven Acute and Chronic Inflammation
por: Ziegon, Laura, et al.
Publicado: (2021)

Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity
por: Wang, Hui, et al.
Publicado: (2012)

Withdrawal: Ceramide stabilizes β-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid β-peptide biogenesis
por: Puglielli, Luigi, et al.
Publicado: (2022)

DNA Damage, Neurodegeneration, and Synaptic Plasticity
por: Merlo, Daniela, et al.
Publicado: (2016)

Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles
por: Groemer, Teja W., et al.
Publicado: (2011)

Antibacterial and β-amyloid precursor protein-cleaving enzyme 1 inhibitory polyketides from the fungus Aspergillus chevalieri
por: Wang, Qing-Yuan, et al.
Publicado: (2022)

Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein
por: Witton, Jonathan, et al.
Publicado: (2010)

Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer’s disease
por: Evin, Genevieve, et al.
Publicado: (2014)

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage
por: Portelius, Erik, et al.
Publicado: (2014)

Amyloid-β Homeostasis Bridges Inflammation, Synaptic Plasticity Deficits and Cognitive Dysfunction in Multiple Sclerosis
por: Stampanoni Bassi, Mario, et al.
Publicado: (2017)

Sevoflurane inhibits cholangiocarcinoma via Wnt/β-catenin signaling pathway
por: Cheng, Hui, et al.
Publicado: (2023)

Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1-AS expression
por: LIU, TE, et al.
Publicado: (2014)

Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease
por: Pradhan, Arpit Kumar, et al.
Publicado: (2023)

Chronic Sodium Selenate Treatment Restores Deficits in Cognition and Synaptic Plasticity in a Murine Model of Tauopathy
por: Ahmed, Tariq, et al.
Publicado: (2020)

Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila
por: Bourdet, Isabelle, et al.
Publicado: (2015)

Aβ/Amyloid Precursor Protein-Induced Hyperexcitability and Dysregulation of Homeostatic Synaptic Plasticity in Neuron Models of Alzheimer’s Disease
por: Martinsson, Isak, et al.
Publicado: (2022)

Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments
por: Wild, Klemens, et al.
Publicado: (2017)

Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis
por: Zou, Chengyu, et al.
Publicado: (2016)

The hammerhead self-cleaving motif as a precursor to complex endonucleolytic ribozymes
por: DasGupta, Saurja, et al.
Publicado: (2021)

Icaritin, an inhibitor of beta-site amyloid cleaving enzyme-1, inhibits secretion of amyloid precursor protein in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway
por: Feng, Fei, et al.
Publicado: (2019)

Amyloid-Beta Mediates Homeostatic Synaptic Plasticity
por: Galanis, Christos, et al.
Publicado: (2021)

Stable cerebrospinal fluid neurogranin and β-site amyloid precursor protein cleaving enzyme 1 levels differentiate predementia Alzheimer’s disease patients
por: Kirsebom, Bjørn Eivind, et al.
Publicado: (2022)

Interneurons: Role in Maintaining and Restoring Synaptic Plasticity
por: Calcagnotto, Maria Elisa
Publicado: (2016)

Butyric Acid Precursor Tributyrin Modulates Hippocampal Synaptic Plasticity and Prevents Spatial Memory Deficits: Role of PPARγ and AMPK
por: Belén Sanz-Martos, Ana, et al.
Publicado: (2022)

Translational potential of synaptic alterations in Alzheimer’s disease patients and amyloid precursor protein knock-in mice
por: Medina-Vera, Dina, et al.
Publicado: (2023)

Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits
por: Wu, Yifan, et al.
Publicado: (2019)

Synaptic nanomodules underlie the organization and plasticity of spine synapses
por: Hruska, Martin, et al.
Publicado: (2018)

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
por: Pandey, Poomy, et al.
Publicado: (2016)

Propofol and Sevoflurane Differentially Modulate Cortical Depolarization following Electric Stimulation of the Ventrobasal Thalamus
por: Kratzer, Stephan, et al.
Publicado: (2017)

The amyloid precursor protein: beyond amyloid
por: Zheng, Hui, et al.
Publicado: (2006)

Autophagic Degradation Deficit Involved in Sevoflurane-Induced Amyloid Pathology and Spatial Learning Impairment in APP/PS1 Transgenic Mice
por: Geng, Pengcheng, et al.
Publicado: (2018)

β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice
por: Ye, Jian-Ya, et al.
Publicado: (2020)

A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome
por: Garcia, Octavio, et al.
Publicado: (2010)

Safety, Tolerability, and Pharmacokinetics of the β‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1 Inhibitor Verubecestat (MK‐8931) in Healthy Elderly Male and Female Subjects
por: Forman, Mark, et al.
Publicado: (2019)

Modified (−)-gallocatechin gallate-enriched green tea extract rescues age-related cognitive deficits by restoring hippocampal synaptic plasticity
por: Ahn, Ji-Woong, et al.
Publicado: (2022)

Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis
por: Ishii, Takenobu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_39vfe3eda6581ecsnve8t8h2se