Dispirooxindole-β-Lactams: Synthesis via Staudinger Ketene-Imine Cycloaddition and Biological Evaluation

In this work, we present the first synthesis of dispirooxindole-β-lactams employing optimized methodology of one-pot Staudinger ketene-imine cycloaddition with N-aryl-2-oxo-pyrrolidine-3-carboxylic acids as the ketene source. Spiroconjugation of indoline-2-one with β-lactams ring is considered to be...

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Detalles Bibliográficos
Autores principales: Filatov, Vadim E., Iuzabchuk, Dmitrii A., Tafeenko, Viktor A., Grishin, Yuri K., Roznyatovsky, Vitaly A., Lukianov, Dmitrii A., Fedotova, Yulia A., Sukonnikov, Maxim A., Skvortsov, Dmitry A., Zyk, Nikolai V., Beloglazkina, Elena K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223813/
https://www.ncbi.nlm.nih.gov/pubmed/35743110
http://dx.doi.org/10.3390/ijms23126666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223813/
https://www.ncbi.nlm.nih.gov/pubmed/35743110
http://dx.doi.org/10.3390/ijms23126666

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