Cargando…

Synthesis and Anti-Cancer Activity of New Pyrazolinyl-Indole Derivatives: Pharmacophoric Interactions and Docking Studies for Identifying New EGFR Inhibitors

Newly designed series of indole-containing pyrazole analogs, pyrazolinylindoles, were synthesized, and their structures were confirmed based on the spectral data of the (1)H NMR, (13)C NMR, and HR-MS analyses. Preliminary anti-cancer activity testings were carried out by the National Cancer Institut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khalilullah, Habibullah, Agarwal, Deepak K., Ahsan, Mohamed J., Jadav, Surender S., Mohammed, Hamdoon A., Khan, Masood Alam, Mohammed, Salman A. A., Khan, Riaz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223872/ https://www.ncbi.nlm.nih.gov/pubmed/35742992 http://dx.doi.org/10.3390/ijms23126548

Ejemplares similares

Synthesis, Characterisation, and In Vitro Anticancer Activity of Curcumin Analogues Bearing Pyrazole/Pyrimidine Ring Targeting EGFR Tyrosine Kinase
por: Ahsan, Mohamed Jawed, et al.
Publicado: (2013)

New Biologically Hybrid Pharmacophore Thiazolidinone-Based Indole Derivatives: Synthesis, In Vitro Alpha-Amylase and Alpha-Glucosidase along with Molecular Docking Investigations
por: Khan, Shoaib, et al.
Publicado: (2022)

In Vitro and In Vivo Anti-Breast Cancer Activities of Some Synthesized Pyrazolinyl-estran-17-one Candidates
por: Amr, Abd El-Galil E., et al.
Publicado: (2018)

In Vivo and In Silico Analgesic Activity of Ficus populifolia Extract Containing 2-O-β-D-(3′,4′,6′-Tri-acetyl)-glucopyranosyl-3-methyl Pentanoic Acid
por: Mohammed, Hamdoon A., et al.
Publicado: (2023)

PharmDock: a pharmacophore-based docking program
por: Hu, Bingjie, et al.
Publicado: (2014)

Anthocyanins: Traditional Uses, Structural and Functional Variations, Approaches to Increase Yields and Products’ Quality, Hepatoprotection, Liver Longevity, and Commercial Products
por: Mohammed, Hamdoon A., et al.
Publicado: (2022)

Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking
por: Lee, In Won, et al.
Publicado: (2017)

Pharmacophore and docking-based sequential virtual screening for the identification of novel Sigma 1 receptor ligands
por: Alamri, Mubarak A, et al.
Publicado: (2019)

Pharmacophore-Based Similarity Scoring for DOCK
por: Jiang, Lingling, et al.
Publicado: (2014)

Search for the Pharmacophore of Histone Deacetylase Inhibitors Using Pharmacophore Query and Docking Study
por: Haji Agha Bozorgi, Atefeh, et al.
Publicado: (2014)

Indole Derivatives: Unveiling New Frontiers in Medicinal and Synthetic Organic Chemistry
por: Saleem, Faiza, et al.
Publicado: (2023)

Towards the discovery of potential RdRp inhibitors for the treatment of COVID-19: structure guided virtual screening, computational ADME and molecular dynamics study
por: Alam, Aftab, et al.
Publicado: (2022)

Salt-Tolerant Plants, Halophytes, as Renewable Natural Resources for Cancer Prevention and Treatment: Roles of Phenolics and Flavonoids in Immunomodulation and Suppression of Oxidative Stress towards Cancer Management
por: Mohammed, Hamdoon A., et al.
Publicado: (2023)

pDOCK: a new technique for rapid and accurate docking of peptide ligands to Major Histocompatibility Complexes
por: Khan, Javed Mohammed, et al.
Publicado: (2010)

Layer-by-Layer Nanoparticles of Tamoxifen and Resveratrol for Dual Drug Delivery System and Potential Triple-Negative Breast Cancer Treatment
por: Al-jubori, Ali A., et al.
Publicado: (2021)

Role of Indole Scaffolds as Pharmacophores in the Development of Anti-Lung Cancer Agents
por: Dhuguru, Jyothi, et al.
Publicado: (2020)

Synthesis, antimicrobial activity, pharmacophore modeling and molecular docking studies of new pyrazole-dimedone hybrid architectures
por: Barakat, Assem, et al.
Publicado: (2018)

New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy
por: Poli, Giulio, et al.
Publicado: (2021)

Drying Induced Impact on Composition and Oil Quality of Rosemary Herb, Rosmarinus Officinalis Linn
por: Mohammed, Hamdoon A., et al.
Publicado: (2020)

Combining docking with pharmacophore filtering for improved virtual screening
por: Peach, Megan L, et al.
Publicado: (2009)

Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives
por: Taha, Muhammad, et al.
Publicado: (2019)

Galangin/β-Cyclodextrin Inclusion Complex as a Drug-Delivery System for Improved Solubility and Biocompatibility in Breast Cancer Treatment
por: Abbas, Zainab S., et al.
Publicado: (2022)

Mechanochemical Synthesis and Molecular Docking Studies of New Azines Bearing Indole as Anticancer Agents
por: Ibrahim, Mohamed S., et al.
Publicado: (2023)

Ligand-Based Pharmacophore Modeling, Molecular Docking, and Molecular Dynamic Studies of Dual Tyrosine Kinase Inhibitor of EGFR and VEGFR2
por: Sangande, Frangky, et al.
Publicado: (2020)

Preparation of Iron Oxide and Titania-Based Composite, Core-Shell Populated, Nanoparticulates Material by Two-Step LASER Ablation in Aqueous Media as Antimicrobial and Anticancer Agents
por: Bahjat, Hasan H., et al.
Publicado: (2022)

Docking Studies of Phthalimide Pharmacophore as a Sodium Channel Blocker
por: Iman, Maryam, et al.
Publicado: (2013)

Pharmacophore elucidation and molecular docking studies on phosphodiesterase-5 inhibitors
por: Radwan, Awwad Abdoh
Publicado: (2015)

Gold Nanoparticles and Graphene Oxide Flakes Synergistic Partaking in Cytosolic Bactericidal Augmentation: Role of ROS and NOX2 Activity
por: Al Rugaie, Osamah, et al.
Publicado: (2021)

Chemical Profiling and Molecular Docking Study of Agathophora alopecuroides
por: Amin, Elham, et al.
Publicado: (2022)

Safety and Therapeutic Efficacy of Thymoquinone-Loaded Liposomes against Drug-Sensitive and Drug-Resistant Acinetobacter baumannii
por: Allemailem, Khaled S., et al.
Publicado: (2021)

New Peptide-Based Pharmacophore Activates 20S Proteasome
por: Osmulski, Paweł A., et al.
Publicado: (2020)

SPIONs Conjugate Supported Anticancer Drug Doxorubicin’s Delivery: Current Status, Challenges, and Prospects
por: Akhtar, Naseem, et al.
Publicado: (2022)

Bimetallic Iron–Palladium Catalyst System as a Lewis-Acid for the Synthesis of Novel Pharmacophores Based Indole Scaffold as Anticancer Agents
por: Islam, Mohammad Shahidul, et al.
Publicado: (2021)

E-Pharmacophore mapping and docking studies on Vitamin D receptor (VDR)
por: Nagamani, Selvaraman, et al.
Publicado: (2012)

Discovery of YopE Inhibitors by Pharmacophore-Based Virtual Screening and Docking
por: Ozbuyukkaya, Gizem, et al.
Publicado: (2013)

In silico Discovery of Novel FXa Inhibitors by Pharmacophore Modeling and Molecular Docking
por: Pu, Yinglan, et al.
Publicado: (2017)

Bis-pharmacophore of cinnamaldehyde-clubbed thiosemicarbazones as potent carbonic anhydrase-II inhibitors
por: Rasool, Asif, et al.
Publicado: (2022)

Analytical Purity Determinations of Universal Food-Spice Curcuma longa through a QbD Validated HPLC Approach with Critical Parametric Predictors and Operable-Design’s Monte Carlo Simulations: Analysis of Extracts, Forced-Degradants, and Capsules and Tablets-Based Pharmaceutical Dosage Forms
por: Mohammed, Hamdoon A., et al.
Publicado: (2023)

Pharmacophore Modeling and Molecular Docking Studies on Pinus roxburghii as a Target for Diabetes Mellitus
por: Kaushik, Pawan, et al.
Publicado: (2014)

Copper Oxide Nanoparticle-Decorated Carbon Nanoparticle Composite Colloidal Preparation through Laser Ablation for Antimicrobial and Antiproliferative Actions against Breast Cancer Cell Line, MCF-7
por: Mohammed, Salman A. A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_v00m9li1f644pg2nmk9ec294gr