Trastuzumab and Doxorubicin Sequential Administration Increases Oxidative Stress and Phosphorylation of Connexin 43 on Ser368

Human epidermal growth factor receptor-2 (HER2) is overexpressed in up to 30% of breast cancer cases, causing a more aggressive tumour growth and poor prognosis. Trastuzumab, the humanized antibody targeted to HER2, increased the life expectancy of patients, but severe cardiotoxicity emerged as a lo...

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Detalles Bibliográficos
Autores principales: Pecoraro, Michela, Marzocco, Stefania, Franceschelli, Silvia, Popolo, Ada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224207/
https://www.ncbi.nlm.nih.gov/pubmed/35742818
http://dx.doi.org/10.3390/ijms23126375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224207/
https://www.ncbi.nlm.nih.gov/pubmed/35742818
http://dx.doi.org/10.3390/ijms23126375

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