Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels

Mutations in optineurin, a ubiquitin-binding adaptor protein, cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of motor neurons linked to chronic inflammation and protein aggregation. The majority of ALS patients, including those carrying the optineurin mutations, exhibit...

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Detalles Bibliográficos
Autores principales: Prtenjaca, Nikolina, Rob, Matea, Alam, Muhammad S., Markovinovic, Andrea, Stuani, Cristiana, Buratti, Emanuele, Munitic, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224222/
https://www.ncbi.nlm.nih.gov/pubmed/35743272
http://dx.doi.org/10.3390/ijms23126829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224222/
https://www.ncbi.nlm.nih.gov/pubmed/35743272
http://dx.doi.org/10.3390/ijms23126829

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