Cargando…

DKK-1 Is Underexpressed in Mesenchymal Stem Cells from Patients with Ankylosing Spondylitis and Further Downregulated by IL-17

Dickkopf-1 (Dkk-1) is a key regulator of bone remodeling in spondyloarthropathies. Nevertheless, data regarding its expression in cells of pathophysiologic relevance, such as mesenchymal stem cells (MSCs), are lacking. Herein, we aimed to address DKK1 gene expression and Wnt pathway activation in MS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Daoussis, Dimitrios, Kanellou, Anastasia, Panagiotopoulos, Elias, Papachristou, Dionysios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224314/ https://www.ncbi.nlm.nih.gov/pubmed/35743102 http://dx.doi.org/10.3390/ijms23126660

Ejemplares similares

B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis
por: Daoussis, Dimitrios, et al.
Publicado: (2016)

DNA methylation of DKK‐1 may correlate with pathological bone formation in ankylosing spondylitis
por: Zou, Yu‐Cong, et al.
Publicado: (2023)

New insights into IL-17/IL-23 signaling in ankylosing spondylitis (Review)
por: Chisălău, Beatrice Andreea, et al.
Publicado: (2020)

Molecular Mechanisms of New Bone Formation in Axial Spondyloarthritis
por: Klavdianou, Kalliopi, et al.
Publicado: (2022)

Serum DKK-1 level in the development of ankylosing spondylitis and rheumatic arthritis: a meta-analysis
por: Zhang, Li, et al.
Publicado: (2016)

Serum DKK-1 level in ankylosing spondylitis: insights from meta-analysis and Mendelian randomization
por: Fang, Xi, et al.
Publicado: (2023)

Biological and genetic evaluation of IL-23/IL-17 pathway in ankylosing spondylitis patients
por: DEVECI, HULYA, et al.
Publicado: (2020)

The TNF-NF-kB-DKK1 Axis Promoted Bone Formation in the Enthesis of Ankylosing Spondylitis
por: Jo, Sungsin, et al.
Publicado: (2021)

Dkk1: A key molecule in joint remodelling and fibrosis
por: Klavdianou, Kalliopi, et al.
Publicado: (2017)

Interleukin-17 Inhibitors for the Treatment of Ankylosing Spondylitis
por: Huang, Jin-Xian, et al.
Publicado: (2020)

Altered expression of microRNAs targeting Dkk-1 in peripheral blood mononuclear cells of patients with ankylosing spondylitis
por: Huang, Jinxian, et al.
Publicado: (2019)

IL-23/Th17 axis is not influenced by TNF-blocking agents in ankylosing spondylitis patients
por: Milanez, Fernanda Manente, et al.
Publicado: (2016)

Neutrophil Extracellular Traps and Interleukin 17 in Ankylosing Spondylitis
por: Papagoras, Charalampos, et al.
Publicado: (2021)

Influence of IL10 (rs1800896) Polymorphism and TNF-α, IL-10, IL-17A, and IL-17F Serum Levels in Ankylosing Spondylitis
por: Braga, Matheus, et al.
Publicado: (2021)

Ankylosing spondylitis
Publicado: (1980)

Ankylosing spondylitis
por: Edavalath, Mukesh
Publicado: (2010)

Ankylosing Spondylitis
por: Whitfield, A. G. W.
Publicado: (1976)

Ankylosing Spondylitis
por: Ebrahimiadib, Nazanin, et al.
Publicado: (2021)

IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population
por: Yang, Bin, et al.
Publicado: (2017)

IL23R gene variants in relation to IL17A levels and clinical phenotype in patients with ankylosing spondylitis
por: Nossent, Johannes C, et al.
Publicado: (2018)

Immune activation of characteristic gut mycobiota Kazachstania pintolopesii on IL-23/IL-17R signaling in ankylosing spondylitis
por: Zhang, Haiting, et al.
Publicado: (2022)

Tail suspension delays ectopic ossification in proteoglycan-induced ankylosing spondylitis in mice via miR-103/DKK1
por: Zhang, Zhenzhen, et al.
Publicado: (2021)

A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis
por: Vidal-Castiñeira, Jose Ramón, et al.
Publicado: (2016)

IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis
por: Jo, Sungsin, et al.
Publicado: (2018)

Efficacy and safety of IL-17 inhibitors for the treatment of ankylosing spondylitis: a systematic review and meta-analysis
por: Yin, Yufeng, et al.
Publicado: (2020)

Polymorphisms within Genes Coding for IL-17A and F and Their Receptor as Clinical Hallmarks in Ankylosing Spondylitis
por: Wielińska, Joanna, et al.
Publicado: (2021)

Serum IL-6 correlates with axial mobility index (Bath Ankylosing Spondylitis Metrology Index) in Brazilian patients with ankylosing spondylitis
por: Rabelo, Cristina F, et al.
Publicado: (2018)

Why Inhibition of IL-23 Lacked Efficacy in Ankylosing Spondylitis
por: McGonagle, Dennis, et al.
Publicado: (2021)

Increased IL-22- and IL-17A-Producing Mucosal-Associated Invariant T Cells in the Peripheral Blood of Patients With Ankylosing Spondylitis
por: Toussirot, Éric, et al.
Publicado: (2018)

Clinical Significance of Peripheral Blood Th1 and Th17 Cell Content and Serum IL-35 and IL-17 Expression in Patients with Ankylosing Spondylitis
por: Tan, Haitao, et al.
Publicado: (2022)

Imaging of ankylosing spondylitis
por: Østergaard, Mikkel
Publicado: (2012)

Alexithymia in ankylosing spondylitis
por: Karabıçak, Deniz, et al.
Publicado: (2021)

Is there a link between IL-23/IL-17 and developmental pathways such as the Wnt and Hedgehog pathway?
por: Stamatis-Liossis, Nicholas, et al.
Publicado: (2017)

Retracted: Clinical Significance of Peripheral Blood Th1 and Th17 Cell Content and Serum IL-35 and IL-17 Expression in Patients with Ankylosing Spondylitis
por: and Alternative Medicine, Evidence-Based Complementary
Publicado: (2023)

miR-148a-3p facilitates osteogenic differentiation of fibroblasts in ankylosing spondylitis by activating the Wnt pathway and targeting DKK1
por: Sheng, Wenbo, et al.
Publicado: (2022)

IL-23 Inhibition in Ankylosing Spondylitis: Where Did It Go Wrong?
por: Baeten, Dominique, et al.
Publicado: (2021)

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
por: Cortes, Adrian, et al.
Publicado: (2015)

Genetic factors involved in the co‑occurrence of endometriosis with ankylosing spondylitis (Review)
por: Zervou, Maria I., et al.
Publicado: (2023)

Update on the treatment of ankylosing spondylitis
por: Maksymowych, Walter P
Publicado: (2007)

Ankylosing spondylitis: yesterday and today.
por: Spencer, D G, et al.
Publicado: (1980)

Cannot write session to /tmp/vufind_sessions/sess_kt94ikllf23m0coi74jn9tk6qs