Cargando…
CX3CL1 Action on Microglia Protects from Diet-Induced Obesity by Restoring POMC Neuronal Excitability and Melanocortin System Activity Impaired by High-Fat Diet Feeding
Both hypothalamic microglial inflammation and melanocortin pathway dysfunction contribute to diet-induced obesity (DIO) pathogenesis. Previous studies involving models of altered microglial signaling demonstrate altered DIO susceptibility with corresponding POMC neuron cytological changes, suggestin...
Autores principales: | Banerjee, Jineta, Dorfman, Mauricio D., Fasnacht, Rachael, Douglass, John D., Wyse-Jackson, Alice C., Barria, Andres, Thaler, Joshua P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224384/ https://www.ncbi.nlm.nih.gov/pubmed/35742824 http://dx.doi.org/10.3390/ijms23126380 |
Ejemplares similares
-
Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation
por: Douglass, J.D., et al.
Publicado: (2017) -
Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
por: Dorfman, Mauricio D., et al.
Publicado: (2017) -
Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss
por: Michael, Natalie Jane, et al.
Publicado: (2017) -
Microglia and Aging: The Role of the TREM2–DAP12 and CX3CL1-CX3CR1 Axes
por: Mecca, Carmen, et al.
Publicado: (2018) -
Defective regulation of POMC precedes hypothalamic inflammation in diet-induced obesity
por: Souza, Gabriela F. P., et al.
Publicado: (2016)