Untangling the Conformational Plasticity of V66M Human proBDNF Polymorphism as a Modifier of Psychiatric Disorder Susceptibility

The human genetic variant BDNF (V66M) represents the first example of neurotrophin family member that has been linked to psychiatric disorders. In order to elucidate structural differences that account for the effects in cognitive function, this hproBDNF polymorph was expressed, refolded, purified,...

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Detalles Bibliográficos
Autores principales: Covaceuszach, Sonia, Peche, Leticia Yamila, Konarev, Petr Valeryevich, Grdadolnik, Joze, Cattaneo, Antonino, Lamba, Doriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224406/
https://www.ncbi.nlm.nih.gov/pubmed/35743044
http://dx.doi.org/10.3390/ijms23126596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224406/
https://www.ncbi.nlm.nih.gov/pubmed/35743044
http://dx.doi.org/10.3390/ijms23126596

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