Bulge-Forming miRNases Cleave Oncogenic miRNAs at the Central Loop Region in a Sequence-Specific Manner

The selective degradation of disease-associated microRNA is promising for the development of new therapeutic approaches. In this study, we engineered a series of bulge-loop-forming oligonucleotides conjugated with catalytic peptide [(LeuArg)(2)Gly](2) (BC–miRNases) capable of recognizing and destroy...

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Detalles Bibliográficos
Autores principales: Patutina, Olga, Chiglintseva, Daria, Amirloo, Bahareh, Clarke, David, Gaponova, Svetlana, Vlassov, Valentin, Bichenkova, Elena, Zenkova, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224474/
https://www.ncbi.nlm.nih.gov/pubmed/35743015
http://dx.doi.org/10.3390/ijms23126562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224474/
https://www.ncbi.nlm.nih.gov/pubmed/35743015
http://dx.doi.org/10.3390/ijms23126562

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