A Homozygous Loss-of-Function Mutation in MSH5 Abolishes MutSγ Axial Loading and Causes Meiotic Arrest in NOA-Affected Individuals

Non-obstructive azoospermia (NOA), characterized by spermatogenesis failure and the absence of sperm in ejaculation, is the most severe form of male infertility. However, the etiology and pathology between meiosis-associated monogenic alterations and human NOA remain largely unknown. A homozygous MS...

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Detalles Bibliográficos
Autores principales: Gong, Chenjia, Abbas, Tanveer, Muhammad, Zubair, Zhou, Jianteng, Khan, Ranjha, Ma, Hui, Zhang, Huan, Shi, Qinghua, Shi, Baolu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224491/
https://www.ncbi.nlm.nih.gov/pubmed/35742973
http://dx.doi.org/10.3390/ijms23126522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224491/
https://www.ncbi.nlm.nih.gov/pubmed/35742973
http://dx.doi.org/10.3390/ijms23126522

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