Loss of Heterozygosity for Kras(G12D) Promotes Malignant Phenotype of Pancreatic Ductal Adenocarcinoma by Activating HIF-2α-c-Myc-Regulated Glutamine Metabolism

Loss of heterozygosity (LOH) for KRAS, in which a wild-type KRAS allele is progressively lost, promotes invasive and migratory abilities of pancreatic ductal adenocarcinoma (PDAC) cells and tissues. Moreover, the occurrence of Kras(G12D)-LOH activates nonclassical glutamine metabolism, which is rela...

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Detalles Bibliográficos
Autores principales: Ma, Yu, Ling, Sunkai, Li, Yuan, Hu, Mingyue, Kong, Bo, Huang, Peilin, Liu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224498/
https://www.ncbi.nlm.nih.gov/pubmed/35743139
http://dx.doi.org/10.3390/ijms23126697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224498/
https://www.ncbi.nlm.nih.gov/pubmed/35743139
http://dx.doi.org/10.3390/ijms23126697

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