New Insights into the Determinants of Specificity in Human Type I Arginase: Generation of a Mutant That Is Only Active with Agmatine as Substrate

Arginase catalyzes the hydrolysis of L-arginine into L-ornithine and urea. This enzyme has several analogies with agmatinase, which catalyzes the hydrolysis of agmatine into putrescine and urea. However, this contrasts with the highlighted specificity that each one presents for their respective subs...

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Detalles Bibliográficos
Autores principales: Orellana, María-Soledad, Jaña, Gonzalo A., Figueroa, Maximiliano, Martínez-Oyanedel, José, Medina, Fabiola E., Tarifeño-Saldivia, Estefanía, Gatica, Marcell, García-Robles, María Ángeles, Carvajal, Nelson, Uribe, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224512/
https://www.ncbi.nlm.nih.gov/pubmed/35742891
http://dx.doi.org/10.3390/ijms23126438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224512/
https://www.ncbi.nlm.nih.gov/pubmed/35742891
http://dx.doi.org/10.3390/ijms23126438

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