Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis

Systemic sclerosis (SSc) is characterized by excessive collagen deposition in the skin and internal organs. Activated fibroblasts are the key effector cells for the overproduction of type I collagen, which comprises the α1(I) and α2(I) chains encoded by COL1A1 and COL1A2, respectively. In this study...

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Detalles Bibliográficos
Autores principales: Sawamura, Soichiro, Makino, Katsunari, Ide, Maho, Shimada, Shuichi, Kajihara, Ikko, Makino, Takamitsu, Jinnin, Masatoshi, Fukushima, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224560/
https://www.ncbi.nlm.nih.gov/pubmed/35743254
http://dx.doi.org/10.3390/ijms23126811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224560/
https://www.ncbi.nlm.nih.gov/pubmed/35743254
http://dx.doi.org/10.3390/ijms23126811

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