Genetic Variations of the DPYD Gene and Its Relationship with Ancestry Proportions in Different Ecuadorian Trihybrid Populations

Dihydropyrimidine dehydrogenase is one of the main pharmacological metabolizers of fluoropyrimidines, a group of drugs widely used in clinical oncology. Around 20 to 30% of patients treated with fluoropyrimidines experience severe toxicity caused by a partial or total decrease in enzymatic activity....

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Detalles Bibliográficos
Autores principales: Farinango, Camila, Gallardo-Cóndor, Jennifer, Freire-Paspuel, Byron, Flores-Espinoza, Rodrigo, Jaramillo-Koupermann, Gabriela, López-Cortés, Andrés, Burgos, Germán, Tejera, Eduardo, Cabrera-Andrade, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225136/
https://www.ncbi.nlm.nih.gov/pubmed/35743735
http://dx.doi.org/10.3390/jpm12060950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225136/
https://www.ncbi.nlm.nih.gov/pubmed/35743735
http://dx.doi.org/10.3390/jpm12060950

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