Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics

Antibody-directed nanotherapeutics (ADNs) represent a promising delivery platform for selective delivery of an encapsulated drug payload to the site of disease that improves the therapeutic index. Although both single-chain Fv (scFv) and Fab antibody fragments have been used for targeting, no platfo...

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Detalles Bibliográficos
Autores principales: Geddie, Melissa L., Kirpotin, Dmitri B., Kohli, Neeraj, Kornaga, Tad, Boll, Bjoern, Razlog, Maja, Drummond, Daryl C., Lugovskoy, Alexey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225506/
https://www.ncbi.nlm.nih.gov/pubmed/35708974
http://dx.doi.org/10.1080/19420862.2022.2083466

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