α-Synuclein A53T Promotes Mitochondrial Proton Gradient Dissipation and Depletion of the Organelle Respiratory Reserve in a Neuroblastoma Cell Line

α-synuclein (αSyn) is a small neuronal protein whose accumulation correlates with Parkinson’s disease. αSyn A53T mutant impairs mitochondrial functions by affecting substrate import within the organelle, activity of complex I and the maximal respiratory capacity. However, the precise mechanism initi...

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Detalles Bibliográficos
Autores principales: Risiglione, Pierpaolo, Cubisino, Salvatore Antonio Maria, Lipari, Cristiana Lucia Rita, De Pinto, Vito, Messina, Angela, Magrì, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225574/
https://www.ncbi.nlm.nih.gov/pubmed/35743925
http://dx.doi.org/10.3390/life12060894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225574/
https://www.ncbi.nlm.nih.gov/pubmed/35743925
http://dx.doi.org/10.3390/life12060894

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