Design, synthesis, and biological evaluation of a novel series of 2-(2,6-dioxopiperidin-3-yl)isoquinoline-1,3(2H,4H)-dione derivatives as cereblon modulators

In the current study, we designed and synthesised a novel series of 2-(2,6-dioxopiperidin-3-yl)isoquinoline-1,3(2H,4H)-dione derivatives as cereblon (CRBN) modulators. The results of the CCK8 assay revealed potent antiproliferative activity for the selected compound 10a against NCI-H929 (IC(50)=2.25...

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Detalles Bibliográficos
Autores principales: Liu, Yilin, Song, Yuming, Xu, Yingju, Jiang, Meixu, Lu, Haibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225785/
https://www.ncbi.nlm.nih.gov/pubmed/35698881
http://dx.doi.org/10.1080/14756366.2022.2087219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225785/
https://www.ncbi.nlm.nih.gov/pubmed/35698881
http://dx.doi.org/10.1080/14756366.2022.2087219

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