CRISPR activation screen identifies TGFβ-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma

As the second most common pediatric bone and soft tissue tumor, Ewing sarcoma (ES) is an aggressive disease with a pathognomonic chromosomal translocation t(11;22) resulting in expression of EWS-FLI1, an “undruggable” fusion protein acting as transcriptional modulator. EWS-FLI1 rewires the protein e...

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Detalles Bibliográficos
Autores principales: Saratov, Vadim, Ngo, Quy A., Pedot, Gloria, Sidorov, Semjon, Wachtel, Marco, Niggli, Felix K., Schäfer, Beat W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225990/
https://www.ncbi.nlm.nih.gov/pubmed/35739280
http://dx.doi.org/10.1038/s41598-022-12659-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225990/
https://www.ncbi.nlm.nih.gov/pubmed/35739280
http://dx.doi.org/10.1038/s41598-022-12659-7

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