Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit

Imbalanced mitochondrial dNTP pools are known players in the pathogenesis of multiple human diseases. Here we show that, even under physiological conditions, dGTP is largely overrepresented among other dNTPs in mitochondria of mouse tissues and human cultured cells. In addition, a vast majority of m...

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Detalles Bibliográficos
Autores principales: Molina-Granada, David, González-Vioque, Emiliano, Dibley, Marris G., Cabrera-Pérez, Raquel, Vallbona-Garcia, Antoni, Torres-Torronteras, Javier, Sazanov, Leonid A., Ryan, Michael T., Cámara, Yolanda, Martí, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226000/
https://www.ncbi.nlm.nih.gov/pubmed/35739187
http://dx.doi.org/10.1038/s42003-022-03568-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226000/
https://www.ncbi.nlm.nih.gov/pubmed/35739187
http://dx.doi.org/10.1038/s42003-022-03568-6

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