Lipid A analog CRX-527 conjugated to synthetic peptides enhances vaccination efficacy and tumor control

Adjuvants play a determinant role in cancer vaccination by optimally activating APCs and shaping the T cell response. Bacterial-derived lipid A is one of the most potent immune-stimulators known, and is recognized via Toll-like receptor 4 (TLR4). In this study, we explore the use of the synthetic, n...

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Detalles Bibliográficos
Autores principales: Tondini, Elena, Reintjens, Niels R. M., Castello, Giulia, Arakelian, Tsolere, Isendoorn, Marjolein, Camps, Marcel, Vree, Jana, van der Marel, Gijs A., Filippov, Dmitri V., Codee, Jeroen D. C., Ossendorp, Ferry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226002/
https://www.ncbi.nlm.nih.gov/pubmed/35739113
http://dx.doi.org/10.1038/s41541-022-00484-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226002/
https://www.ncbi.nlm.nih.gov/pubmed/35739113
http://dx.doi.org/10.1038/s41541-022-00484-y

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