Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling

Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase RIPK3. To mediate necroptosis, RIPK3 must stably interact with, and phosphorylate the pseudokinase domain of MLKL, althou...

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Detalles Bibliográficos
Autores principales: Meng, Yanxiang, Horne, Christopher R., Samson, Andre L., Dagley, Laura F., Young, Samuel N., Sandow, Jarrod J., Czabotar, Peter E., Murphy, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226014/
https://www.ncbi.nlm.nih.gov/pubmed/35739084
http://dx.doi.org/10.1038/s41419-022-05009-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226014/
https://www.ncbi.nlm.nih.gov/pubmed/35739084
http://dx.doi.org/10.1038/s41419-022-05009-y

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