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Adipose-Derived Mesenchymal Stem Cells Reprogram M1 Macrophage Metabolism via PHD2/HIF-1α Pathway in Colitis Mice

Ulcerative colitis (UC) is a chronic inflammatory bowel disease worldwide. Infiltration of pro-inflammatory macrophages (M1 macrophages) contributes to the occurrence of bowel inflammation. Transplantation of mesenchymal stem cells (MSCs) is a promising therapeutic strategy for UC, but the exact mec...

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Detalles Bibliográficos
Autores principales: Yuan, Yin, Ni, Shuo, Zhuge, Aoxiang, Li, Lanjuan, Li, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226317/
https://www.ncbi.nlm.nih.gov/pubmed/35757749
http://dx.doi.org/10.3389/fimmu.2022.859806