Peripherally restricted transthyretin-based delivery system for probes and therapeutics avoiding opioid-related side effects

Several investigations into the sites of action of opioid analgesics have utilized peripherally acting mu-opioid receptor antagonists (PAMORAs), which have been incorrectly assumed to possess limited permeability across the blood-brain barrier. Unfortunately, the poor pharmacokinetic properties of c...

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Detalles Bibliográficos
Autores principales: Tuhin, Md Tariqul Haque, Liang, Dengpan, Liu, Fang, Aldawod, Hala, Amin, Toufiq Ul, Ho, Joshua S., Emara, Rasha, Patel, Arjun D., Felmlee, Melanie A., Park, Miki S., Uchizono, James A., Alhamadsheh, Mamoun M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226319/
https://www.ncbi.nlm.nih.gov/pubmed/35739116
http://dx.doi.org/10.1038/s41467-022-31342-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226319/
https://www.ncbi.nlm.nih.gov/pubmed/35739116
http://dx.doi.org/10.1038/s41467-022-31342-z

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