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Peripherally restricted transthyretin-based delivery system for probes and therapeutics avoiding opioid-related side effects
Several investigations into the sites of action of opioid analgesics have utilized peripherally acting mu-opioid receptor antagonists (PAMORAs), which have been incorrectly assumed to possess limited permeability across the blood-brain barrier. Unfortunately, the poor pharmacokinetic properties of c...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226319/ https://www.ncbi.nlm.nih.gov/pubmed/35739116 http://dx.doi.org/10.1038/s41467-022-31342-z |