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DNA replication is highly resilient and persistent under the challenge of mild replication stress

Mitotic DNA synthesis (MiDAS) has been proposed to restart DNA synthesis during mitosis because of replication fork stalling in late interphase caused by mild replication stress (RS). Contrary to this proposal, we find that cells exposed to mild RS in fact maintain continued DNA replication througho...

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Detalles Bibliográficos
Autores principales: Mocanu, Camelia, Karanika, Eleftheria, Fernández-Casañas, María, Herbert, Alex, Olukoga, Tomisin, Özgürses, Mete Emir, Chan, Kok-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226383/
https://www.ncbi.nlm.nih.gov/pubmed/35443178
http://dx.doi.org/10.1016/j.celrep.2022.110701