The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases

The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing and release of pro-inflammatory cytokines IL-1β...

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Detalles Bibliográficos
Autores principales: Blevins, Hallie M., Xu, Yiming, Biby, Savannah, Zhang, Shijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226403/
https://www.ncbi.nlm.nih.gov/pubmed/35754962
http://dx.doi.org/10.3389/fnagi.2022.879021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226403/
https://www.ncbi.nlm.nih.gov/pubmed/35754962
http://dx.doi.org/10.3389/fnagi.2022.879021

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