An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model

Angiotensin Converting Enzyme 2 (ACE2) is the primary cell entry receptor for SARS-CoV and SARS-CoV-2 viruses. A disintegrin and metalloproteinase 17 (ADAM17) is a protease that cleaves ectodomains of transmembrane proteins, including that of ACE2 and the proinflammatory cytokine TNF-α, from cell su...

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Detalles Bibliográficos
Autores principales: Hedges, Jodi F., Snyder, Deann T., Robison, Amanda, Grifka-Walk, Heather M., Blackwell, Karlin, Shepardson, Kelly, Kominsky, Douglas, Rynda-Apple, Agnieszka, Walcheck, Bruce, Jutila, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226444/
https://www.ncbi.nlm.nih.gov/pubmed/35757773
http://dx.doi.org/10.3389/fimmu.2022.918881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226444/
https://www.ncbi.nlm.nih.gov/pubmed/35757773
http://dx.doi.org/10.3389/fimmu.2022.918881

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