Cargando…

An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model

Angiotensin Converting Enzyme 2 (ACE2) is the primary cell entry receptor for SARS-CoV and SARS-CoV-2 viruses. A disintegrin and metalloproteinase 17 (ADAM17) is a protease that cleaves ectodomains of transmembrane proteins, including that of ACE2 and the proinflammatory cytokine TNF-α, from cell su...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hedges, Jodi F., Snyder, Deann T., Robison, Amanda, Grifka-Walk, Heather M., Blackwell, Karlin, Shepardson, Kelly, Kominsky, Douglas, Rynda-Apple, Agnieszka, Walcheck, Bruce, Jutila, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226444/ https://www.ncbi.nlm.nih.gov/pubmed/35757773 http://dx.doi.org/10.3389/fimmu.2022.918881

Ejemplares similares

Getting “Inside” Type I IFNs: Type I IFNs in Intracellular Bacterial Infections
por: Snyder, Deann T., et al.
Publicado: (2017)

Expression of human TLR4/myeloid differentiation factor 2 directs an early innate immune response associated with modest increases in bacterial burden during Coxiella burnetii infection
por: Robison, Amanda, et al.
Publicado: (2019)

Titers, Prevalence, and Duration of SARS-CoV-2 Antibodies in a Local COVID-19 Outbreak and Following Vaccination
por: Hedges, Jodi F., et al.
Publicado: (2021)

Complete Genome Sequence of Brucella abortus Phage EF4, Determined Using Long-Read Sequencing
por: Cicha, Calvin, et al.
Publicado: (2020)

A TLR4 agonist liposome formulation effectively stimulates innate immunity and enhances protection from bacterial infection
por: Hedges, Jodi F., et al.
Publicado: (2023)

Severe Acute Respiratory Syndrome Coronavirus 2 Is Detected in the Gastrointestinal Tract of Asymptomatic Endoscopy Patients but Is Unlikely to Pose a Significant Risk to Healthcare Personnel
por: Cherne, Michelle D., et al.
Publicado: (2022)

651: SARS-COV-2 IS DETECTED IN THE GASTROINTESTINAL TRACT OF ASYMPTOMATIC OUTPATIENTS USING ROUTINE ENDOSCOPY BUT POSES MINIMAL TRANSMISSION RISK
por: Gentry, Andrew B., et al.
Publicado: (2022)

Leukocyte ADAM17 Regulates Acute Pulmonary Inflammation
por: Arndt, Patrick G., et al.
Publicado: (2011)

Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis
por: Mishra, Hemant K., et al.
Publicado: (2017)

Effect of Inactivation Methods on SARS-CoV-2 Virion Protein and Structure
por: Loveday, Emma K., et al.
Publicado: (2021)

Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism
por: Grifka-Walk, Heather M., et al.
Publicado: (2021)

Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation
por: Mishra, Hemant K., et al.
Publicado: (2021)

IFNAR2 Is Required for Anti-influenza Immunity and Alters Susceptibility to Post-influenza Bacterial Superinfections
por: Shepardson, Kelly M., et al.
Publicado: (2018)

Antiviral response mechanisms in a Jamaican Fruit Bat intestinal organoid model of SARS-CoV-2 infection
por: Hashimi, Marziah, et al.
Publicado: (2022)

Differential Type I Interferon Signaling Is a Master Regulator of Susceptibility to Postinfluenza Bacterial Superinfection
por: Shepardson, Kelly M., et al.
Publicado: (2016)

Pathophysiology of Influenza D Virus Infection in Specific-Pathogen-Free Lambs with or without Prior Mycoplasma ovipneumoniae Exposure
por: Robinson, Ema, et al.
Publicado: (2022)

Harnessing γδ T Cells as Natural Immune Modulators
por: Hedges, Jodi F., et al.
Publicado: (2020)

Contribution of Host Immune Responses Against Influenza D Virus Infection Toward Secondary Bacterial Infection in a Mouse Model
por: Skelton, Raegan M., et al.
Publicado: (2019)

ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fibrosis and dysfunction via regulating ACE2 shedding and myofibroblast transformation
por: Cheng, Jing, et al.
Publicado: (2022)

SARS-CoV-2 genomic surveillance identifies naturally occurring truncations of ORF7a that limit immune suppression.
por: Nemudryi, Artem, et al.
Publicado: (2021)

Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis
por: Mishra, Hemant K., et al.
Publicado: (2020)

SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression
por: Nemudryi, Artem, et al.
Publicado: (2021)

Induction of Antiviral Immune Response through Recognition of the Repeating Subunit Pattern of Viral Capsids Is Toll-Like Receptor 2 Dependent
por: Shepardson, Kelly M., et al.
Publicado: (2017)

ADAM17 in tumor associated leukocytes regulates inflammatory mediators and promotes mammary tumor formation
por: Bohrer, Laura R., et al.
Publicado: (2016)

Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection
por: Hashimi, Marziah, et al.
Publicado: (2023)

ADAM 17 endopeptidase
Publicado: (2009)

Identification of an ADAM17 Cleavage Region in Human CD16 (FcγRIII) and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells
por: Jing, Yawu, et al.
Publicado: (2015)

ADAM10 and ADAM17: New Players in Trastuzumab Resistance
por: Duffy, Michael J., et al.
Publicado: (2014)

ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis
por: Van Meenen, Dario, et al.
Publicado: (2022)

Role of ADAM10 and ADAM17 in Regulating CD137 Function
por: Seidel, Jana, et al.
Publicado: (2021)

LRP1 shedding in human brain: roles of ADAM10 and ADAM17
por: Liu, Qiang, et al.
Publicado: (2009)

Upregulation of APP, ADAM10 and ADAM17 in the Denervated Mouse Dentate Gyrus
por: Del Turco, Domenico, et al.
Publicado: (2014)

Influence of Anoctamin-4 and -9 on ADAM10 and ADAM17 Sheddase Function
por: Leitzke, Sinje, et al.
Publicado: (2022)

Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris
por: Kugelmann, Daniela, et al.
Publicado: (2022)

Intrinsic signal amplification by type III CRISPR-Cas systems provides a sequence-specific SARS-CoV-2 diagnostic
por: Santiago-Frangos, Andrew, et al.
Publicado: (2021)

Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids
por: Matthews, Alexandra L., et al.
Publicado: (2017)

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
por: Sahin, Umut, et al.
Publicado: (2004)

Differential Surface Expression of ADAM10 and ADAM17 on Human T Lymphocytes and Tumor Cells
por: Ebsen, Henriette, et al.
Publicado: (2013)

The disintegrin-metalloproteinases ADAM10 and ADAM17 are upregulated in cutaneous squamous cell carcinomas
por: Oh, S.-T., et al.
Publicado: (2016)

ADAM10 and ADAM17 as Biomarkers Linked to Inflammation, Metabolic Disorders and Colorectal Cancer
por: Sikora-Skrabaka, Magdalena, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4ts1f3isvmj4cc10p0h0pdcojq