Cargando…

CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice

Gene expression analyses suggest that more than 1000–2000 genes are expressed predominantly in mouse and human testes. Although functional analyses of hundreds of these genes have been performed, there are still many testis-enriched genes whose functions remain unexplored. Analyzing gene function us...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oyama, Yuki, Miyata, Haruhiko, Shimada, Keisuke, Fujihara, Yoshitaka, Tokuhiro, Keizo, Garcia, Thomas X, Matzuk, Martin M, Ikawa, Masahito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2021
Materias:	Invited Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226692/ https://www.ncbi.nlm.nih.gov/pubmed/34290169 http://dx.doi.org/10.4103/aja.aja_63_21

Ejemplares similares

CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity
por: Park, Soojin, et al.
Publicado: (2020)

CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice
por: Lu, Yonggang, et al.
Publicado: (2019)

CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction(†)
por: Sun, Jiang, et al.
Publicado: (2020)

Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility
por: Morohoshi, Akane, et al.
Publicado: (2023)

Commentary on “CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice”
por: Houston, Brendan J
Publicado: (2021)

CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice
por: Abbasi, Ferheen, et al.
Publicado: (2020)

Testis‐enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa
por: Miyata, Haruhiko, et al.
Publicado: (2020)

IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice
por: Kaneda, Yuki, et al.
Publicado: (2022)

CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice
por: Oji, Asami, et al.
Publicado: (2016)

The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum
por: Miyata, Haruhiko, et al.
Publicado: (2021)

Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR/Cas9
por: Abbasi, Ferheen, et al.
Publicado: (2017)

TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility
por: Oyama, Yuki, et al.
Publicado: (2022)

Advantages of using the CRISPR/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models
por: Young, Samantha AM, et al.
Publicado: (2015)

Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA
por: Mashiko, Daisuke, et al.
Publicado: (2013)

Factors controlling sperm migration through the oviduct revealed by gene-modified mouse models
por: Fujihara, Yoshitaka, et al.
Publicado: (2018)

CRISPR/CAS9-mediated amino acid substitution reveals phosphorylation residues of RSPH6A are not essential for male fertility in mice
por: Miyata, Haruhiko, et al.
Publicado: (2020)

Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models
por: Fujihara, Yoshitaka, et al.
Publicado: (2017)

Genome editing of immune cells using CRISPR/Cas9
por: Kim, Segi, et al.
Publicado: (2021)

Tmprss12 is required for sperm motility and uterotubal junction migration in mice(†)
por: Larasati, Tamara, et al.
Publicado: (2020)

The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility(†)
por: Holcomb, Richard J, et al.
Publicado: (2020)

ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility
por: Shimada, Keisuke, et al.
Publicado: (2021)

Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis
por: SHIMADA, Keisuke, et al.
Publicado: (2019)

Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice
por: Devlin, Darius J, et al.
Publicado: (2020)

CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis
por: Young, Samantha A. M., et al.
Publicado: (2015)

Oocyte-specific Wee1-like protein kinase 2 is dispensable for fertility in mice
por: Nozawa, Kaori, et al.
Publicado: (2023)

The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice
por: Nozawa, Kaori, et al.
Publicado: (2022)

SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice
por: Miyata, Haruhiko, et al.
Publicado: (2021)

Lycopene Is Enriched in Tomato Fruit by CRISPR/Cas9-Mediated Multiplex Genome Editing
por: Li, Xindi, et al.
Publicado: (2018)

Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm−oocyte fusion in mice
por: Noda, Taichi, et al.
Publicado: (2020)

Genome Editing of Babesia bovis Using the CRISPR/Cas9 System
por: Hakimi, Hassan, et al.
Publicado: (2019)

Calreticulin is required for development of the cumulus oocyte complex and female fertility
por: Tokuhiro, Keizo, et al.
Publicado: (2015)

Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice
por: Fujihara, Yoshitaka, et al.
Publicado: (2020)

MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors
por: Tanaka, Takashi, et al.
Publicado: (2018)

Mouse t-complex protein 11 is important for progressive motility in sperm
por: Castaneda, Julio M, et al.
Publicado: (2020)

FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice
por: Morohoshi, Akane, et al.
Publicado: (2021)

Chimeric analysis with newly established EGFP/DsRed2-tagged ES cells identify HYDIN as essential for spermiogenesis in mice
por: Oura, Seiya, et al.
Publicado: (2018)

FBXO24 ensures male fertility by preventing abnormal accumulation of membraneless granules in sperm flagella
por: Kaneda, Yuki, et al.
Publicado: (2023)

CRISPR-Cas9 DNA Base-Editing and Prime-Editing
por: Kantor, Ariel, et al.
Publicado: (2020)

Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG
por: Oura, Seiya, et al.
Publicado: (2021)

TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation
por: Shimada, Keisuke, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1u9v7qk1sop3rla2v0dlje74kb