A Novel Class of HIV-1 Inhibitors Targeting the Vpr-Induced G2-Arrest in Macrophages by New Yeast- and Cell-Based High-Throughput Screening

The human immunodeficiency virus type 1 (HIV-1) accessory protein, Vpr, arrests the cell cycle of the G2 phase, and this Vpr-mediated G2 arrest is implicated in an efficient HIV-1 spread in monocyte-derived macrophages. Here, we screened new candidates for Vpr-targeting HIV-1 inhibitors by using fis...

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Detalles Bibliográficos
Autores principales: Sato, Hirotaka, Murakami, Tomoyuki, Matsuura, Ryosuke, Abe, Masako, Matsuoka, Seiji, Yashiroda, Yoko, Yoshida, Minoru, Akari, Hirofumi, Nagasawa, Yosuke, Takei, Masami, Aida, Yoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227106/
https://www.ncbi.nlm.nih.gov/pubmed/35746791
http://dx.doi.org/10.3390/v14061321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227106/
https://www.ncbi.nlm.nih.gov/pubmed/35746791
http://dx.doi.org/10.3390/v14061321

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