Design, Synthesis and Cytotoxic Activity Evaluation of Newly Synthesized Amides-Based TMP Moiety as Potential Anticancer Agents over HepG2 Cells

A novel series of amides based TMP moiety was designed, synthesized and evaluated for their antiproliferative as well as enzyme inhibition activity. Compounds 6a and 6b showed remarkable cytotoxic activity against HepG2 cells with IC(50) values 0.65 and 0.92 μM, respectively compared with SAHA and C...

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Detalles Bibliográficos
Autores principales: Al-Warhi, Tarfah, Aldhahrani, Adil, Althobaiti, Fayez, Fayad, Eman, Abu Ali, Ola A., Albogami, Sarah, Abu Almaaty, Ali H., Khedr, Amgad I. M., Bukhari, Syed Nasir Abbas, Zaki, Islam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227250/
https://www.ncbi.nlm.nih.gov/pubmed/35745081
http://dx.doi.org/10.3390/molecules27123960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227250/
https://www.ncbi.nlm.nih.gov/pubmed/35745081
http://dx.doi.org/10.3390/molecules27123960

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