Pre-Clinical Evaluation of Tenofovir and Tenofovir Alafenamide for HIV-1 Pre-Exposure Prophylaxis in Foreskin Tissue

Background: HIV-1 pre-exposure prophylaxis (PrEP) has focused predominantly on protective efficacy in receptive sex, with limited research on the dosing requirements for insertive sex. We pre-clinically assessed the ex vivo pharmacokinetic–pharmacodynamic (PK–PD) profile of tenofovir (TFV) and tenof...

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Detalles Bibliográficos
Autores principales: Else, Laura, Penchala, Sujan D., Pillay, Azure-Dee, Seiphetlo, Thabiso B., Lebina, Limakatso, Callebaut, Christian, Minhas, Suks, Morley, Roland, Rashid, Tina, Martinson, Neil, Fox, Julie, Khoo, Saye, Herrera, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227286/
https://www.ncbi.nlm.nih.gov/pubmed/35745857
http://dx.doi.org/10.3390/pharmaceutics14061285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227286/
https://www.ncbi.nlm.nih.gov/pubmed/35745857
http://dx.doi.org/10.3390/pharmaceutics14061285

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