Protocetraric and Salazinic Acids as Potential Inhibitors of SARS-CoV-2 3CL Protease: Biochemical, Cytotoxic, and Computational Characterization of Depsidones as Slow-Binding Inactivators

The study investigated the inhibitory activity of protocetraric and salazinic acids against SARS-CoV-2 3CL(pro). The kinetic parameters were determined by microtiter plate-reading fluorimeter using a fluorogenic substrate. The cytotoxic activity was tested on murine Sertoli TM4 cells. In silico anal...

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Detalles Bibliográficos
Autores principales: Fagnani, Lorenza, Nazzicone, Lisaurora, Bellio, Pierangelo, Franceschini, Nicola, Tondi, Donatella, Verri, Andrea, Petricca, Sabrina, Iorio, Roberto, Amicosante, Gianfranco, Perilli, Mariagrazia, Celenza, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227325/
https://www.ncbi.nlm.nih.gov/pubmed/35745633
http://dx.doi.org/10.3390/ph15060714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227325/
https://www.ncbi.nlm.nih.gov/pubmed/35745633
http://dx.doi.org/10.3390/ph15060714

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