Adenovirus DNA Polymerase Loses Fidelity on a Stretch of Eleven Homocytidines during Pre-GMP Vaccine Preparation

In this study, we invented and construct novel candidate HIV-1 vaccines. Through genetic and protein engineering, we unknowingly constructed an HIV-1-derived transgene with a homopolymeric run of 11 cytidines, which was inserted into an adenovirus vaccine vector. Here, we describe the virus rescue,...

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Detalles Bibliográficos
Autores principales: Hannoun, Zara, Wee, Edmund G., Crook, Alison, Colloca, Stefano, Di Marco, Stefania, Hanke, Tomáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227658/
https://www.ncbi.nlm.nih.gov/pubmed/35746566
http://dx.doi.org/10.3390/vaccines10060960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227658/
https://www.ncbi.nlm.nih.gov/pubmed/35746566
http://dx.doi.org/10.3390/vaccines10060960

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