Direct phosphorylation of benzylic C–H bonds under transition metal-free conditions forming sp(3)C–P bonds

Direct phosphorylation of benzylic C–H bonds was achieved in a biphasic system under transition metal-free conditions. A selective radical/radical sp(3)C–H/P(O)–H cross coupling was proposed, and various substituted toluenes were applicable. The transformation provided a promising method for constru...

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Detalles Bibliográficos
Autores principales: Li, Qiang, Zhao, Chang-Qiu, Chen, Tieqiao, Han, Li-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227801/
https://www.ncbi.nlm.nih.gov/pubmed/35799919
http://dx.doi.org/10.1039/d2ra02812c
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author Li, Qiang
Zhao, Chang-Qiu
Chen, Tieqiao
Han, Li-Biao
author_facet Li, Qiang
Zhao, Chang-Qiu
Chen, Tieqiao
Han, Li-Biao
author_sort Li, Qiang
collection PubMed
description Direct phosphorylation of benzylic C–H bonds was achieved in a biphasic system under transition metal-free conditions. A selective radical/radical sp(3)C–H/P(O)–H cross coupling was proposed, and various substituted toluenes were applicable. The transformation provided a promising method for constructing sp(3)C–P bonds.
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spelling pubmed-92278012022-07-06 Direct phosphorylation of benzylic C–H bonds under transition metal-free conditions forming sp(3)C–P bonds Li, Qiang Zhao, Chang-Qiu Chen, Tieqiao Han, Li-Biao RSC Adv Chemistry Direct phosphorylation of benzylic C–H bonds was achieved in a biphasic system under transition metal-free conditions. A selective radical/radical sp(3)C–H/P(O)–H cross coupling was proposed, and various substituted toluenes were applicable. The transformation provided a promising method for constructing sp(3)C–P bonds. The Royal Society of Chemistry 2022-06-24 /pmc/articles/PMC9227801/ /pubmed/35799919 http://dx.doi.org/10.1039/d2ra02812c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Li, Qiang
Zhao, Chang-Qiu
Chen, Tieqiao
Han, Li-Biao
Direct phosphorylation of benzylic C–H bonds under transition metal-free conditions forming sp(3)C–P bonds
title Direct phosphorylation of benzylic C–H bonds under transition metal-free conditions forming sp(3)C–P bonds
title_full Direct phosphorylation of benzylic C–H bonds under transition metal-free conditions forming sp(3)C–P bonds
title_fullStr Direct phosphorylation of benzylic C–H bonds under transition metal-free conditions forming sp(3)C–P bonds
title_full_unstemmed Direct phosphorylation of benzylic C–H bonds under transition metal-free conditions forming sp(3)C–P bonds
title_short Direct phosphorylation of benzylic C–H bonds under transition metal-free conditions forming sp(3)C–P bonds
title_sort direct phosphorylation of benzylic c–h bonds under transition metal-free conditions forming sp(3)c–p bonds
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227801/
https://www.ncbi.nlm.nih.gov/pubmed/35799919
http://dx.doi.org/10.1039/d2ra02812c
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AT chentieqiao directphosphorylationofbenzylicchbondsundertransitionmetalfreeconditionsformingsp3cpbonds
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